Childhood nephrotic syndrome requires prolonged drug therapy. The treatment of this disorder has two goals: to temper the simptoms and to stop the protein loss. Human albumin infusion, diuretics and a low sodium diet are used to avoid the oedema. Steroids are generally used to stop protein loss, but unfortunatelly this has several side effects. In our case reports, we would like to emphasise the complications of prolonged steroid therapy, which could be considered a iatrogenic harm.