In a case-control study we have followed the relationship of uricaemia and the metabolic syndrome defined according to the diagnostic criteria recommended by the IDF in 2005, the insulin resistance and secondary hyperinsulinemia. At the 217 patients with metabolic syndrome and the 73 healthy persons the value of uric acid in the blood has shown significant differences at both sexes (p<0.02). Hyperuricaemia has been present at more than 64% of the metabolic syndrome cases. The level of uric acid was in slight-moderate but statistically significant correlation with the metabolic parameters considered components of the metabolic syndrome, fasting insulin and insulin resistance indices (rho = 0.17-0.46, p < 0.04). Based on these, we consider that disturbances of uric acid metabolism are associated frequently with the metabolic syndrome diagnosed according to the above mentioned criteria at the studied population. This usually latent (>98%) lab modification must be searched for, and if is present, drugs must be carefully chosen for the treatment of the different components, as some substances have undesired side effects on the levels of uric acid.