Loratadine is a II. generation of antihistaminic active substance. It belongs to the II. group of the Biopharmaceutics Classification System, with low solubility and good permeability. The solubility depends on the pH of the gastrointestinal liquid. Dimethyl-β-cyclodextrin was able to increase the solubility, so the pH-dependence of CDproducts was smaller than the pure substance. The products were prepared from this sparingly soluble pharmacon by means of methods such as physical mixing, kneading and spray drying. This publication details the investigation results of these products. The interactions leading to complex formation between the components of the products were examined by DSC, FTIR, and 1H-NMR methods.