Nisoldipine is a representative of the second generation of 1,4 dihydropyridine derivatives with antihypertensive effect. It has two disadvantages: fotosensibility, which causes the loss of effect, and the slow solubility with influence on bioavailability. To increase the solubility of Nisoldipine we chose the cyclodextrin inclusion complex method. The products were prepared with β-cyclodextrin and RAMEB using two methods: physical mixing and kneading. In case of these products the dissolution was investigated profile in artificial gastric and intestinal medium. The results show that the RAMEB was able to increase the solubility of Nisoldipine.