Introduction: Polycystic ovarian syndrome (POS) is one of the most frequent forms of the chronic anovulatory diseases with androgen excess. Aim of the study: to analyse the efficacy of the metformin therapy upon ovulation and fertility. Material and methods: We followed for 3 years (2004-2006) the metabolic and hormonal changes in POS patients before and after metformin treatment, especially the frequency of the fertilisation. Results: In 50,00% of the cases hyperandrogenism was present, obesity in 28,26%, bradi/amenorrhoea in 32,61% and infertility in 14,13% of the cases. Elevated PRL levels were found in 44,57%, and elevated LH/FSH ratio in 30,43% of the patients. Metformin therapy was applied in 64 patients. After this ovulatory cycles appeared in 8 cases and 4 women got pregnant. Conclusions: The metformin therapy is effective, which proves the role of insulinresistance in the etiology of POS and furthermore supports the fight against one of the causative agents, the insulinresistance.
Keywords: polycystic ovarian syndrome, metformin, fertility