Molecular epidemiologic biomarkers; a new concept in preventive and predictive medicine, chemoprevention of cancers

Written by Fehér Katalin, Prantner Ida, Kiss István, Varjas Tímea, Gyöngyi Zoltán, Perjési Pál, Németh Katalin, Nowrasteh Ghodratollah, Dombi Zsuzsanna, Ember István

A change of paradigm occurred in the field of cancer research due to the rapid development of molecular biology and genetics. The application of molecular methodologies can be efficient in primary prevention of cancers. Before the morphological appearance of cancer certain biologicalgenetic alteration can be detected, which can be recognized as early biomarkers and can be used for the identification of high-risk of cancer. We demonstrate a model which measures early biomarkers on the level of genes. The „short-term” test system indicates the early and potential biological effects of dangerous cancer inducing factors, on the other hand it provides the opportunity for quantitative risk value. It is able to measure the efficiency of applied chemoprofilaxis on the level of genes, so it is fit for testing the efficiency of the intervention and for the qualification of gene-level chemopreventive substances.


Keywords: molecular and predictive epidemiology, early biomarkers, primary prevention, chemoprevention of human cancer, „short-term” test system