Selected thrombophilia screening among patients with venous thromboembolism (VTE)

Written by Puskás Attila, Balogh Zsolt Elek, Hadadi László, Fekete Timea Zita, Kósa Katalin, Nagy Előd Ernő, Bagoly Zsuzsa, Bereczky Zsuzsanna, Kappelmayer János, Muszbek László

In this study thrombophilia screening results of 148 clinically suspect patients were analyzed. The vast majority of the tested patients were young, with venous thrombo-embolism (VTE) in their history. The aim of the study was to assess the rate of positive diagnosis in the case of highly selected screening, to evaluate the prevalence of various thrombophilic states and to determine the sex and age categories of tested patients. The laboratory evaluation was done at the Clinical Research Center of the University of Debrecen, Hungary. In 27,7% of cases no positive laboratory results were found. In contrast, the vast majority of the tested patients had one or more positive primary or secondary thrombophilia test results. The most frequent inherited risk was factor V Leiden mutation. Among positive results, combined thrombophilias were found slightly more frequent, with higher thrombosis risk in this setting. There were more women than men and the younger age categories were predominant. This study highlights again the good cost-benefit ratio of selected thrombophilia screening in case of high clinical suspicion. 


Keywords: venous thromboembolism, thrombophilia, screening

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