A highly complicated activity of the intracellular signal transduction pathways is necessary to the uninhibited progression of tumor cells. Thanks to the progress in molecular pathology we recognize these mechanisms increasingly better and targeted inhibition of signalling becomes possible. One of the most important signal transduction pathways in the development of colorectal cancer drives through the epidermal growth factor receptor (EGFR). Targeted inhibition of this pathway is one of the main directions of recent research.
Keywords: colorectal cancer, metastatic, EGF inhibition