Drug-Induced Arterial Hypertension II (Drugs acting on hormonal regulation and renal functions)

Written by Kun Imre Zoltán, Kun Ildikó, ifj. Kun Imre Zoltán, Szántó Zsuzsanna

The first part of this theme was discussed in an earlier number of this review (Drug-Induced Arterial Hypertension I: Drugs acting on central and autonomic nervous system). Classifying the drugs with hypertensive effect according to the physiological mechanisms that maintain blood pressure ( BP), the capillary fluid shift mechanisms would be the second milestone, but substances that may be mentioned here fit better in other context. Hormonal regulation, as the third landmark, is amply discussed accordingly to its importance: is emphasized the role of RAS, especially of angiotensin II. Then are mentioned arginine-vasopressin, corticosteroids (gluco- and mineralocorticoids), the apparent mineralocorticoid excess caused by glycyrrhizin and carbenoxolone. It is mentioned the hypertension induced by mineralocorticoid-receptor activating mutations, then some aspects of gonadal pathology (oral contraceptives, hormone replacement therapy, some aphrodisiacs); this part ends with thyroid medication (amiodarone, iodine, some thyroid hormone interactions). Last, the fourth part of the paper discusses NSAIDs, inhibitors of calcineurin (cyclosporine, tacrolimus), and erythropoietin, causing hypertension by influencing renal mechanisms.


Keywords: hormonal regulation of blood pressure, steroid hormones, thyroid medication, NSAIDs, cyclosporine, tacrolimus, erythropoietin

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